Perhaps a hypothetical fragility in the context of Alzheimer's disease was regarded as a state distinct from aging in general, as suggested by the angiogenesis hypothesis, which suggests that old age is one state associated with upregulation of angiogenic growth factors, resulting in decreased microcirculation throughout the body. However, research into this task failed to yield the long-awaited therapeutic miracle lead for Alzheimer's disease. The amyloid cascade theory and the vascular hypothesis, which stresses the buildup of Aβ plaques, have dominated research into dementia and aging throughout history. Despite extensive investigation, the pathological origin of Alzheimer's disease remains a mystery. AD is considered to be one of the most serious problems that dementia sufferers face. It causes memory loss, disorientation, and poor mental function. 10 Department of Pharmacy, Faculty of Pharmacy, University of Oradea, Oradea, Romania.Īlzheimer's disease (AD) is a paramount chronic neurodegenerative condition that has been affecting elderly people since the 1900s.9 Chrono-Environment Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, Besançon, France.8 Department of Life Sciences, Presidency University, Kolkata, India.7 School of Health Science, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.6 Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.5 E-Health Research Center, Universidad de Ciencias y Humanidades, Lima, Peru.4 Faculty of Pharmacy and Biochemistry, Academic Department of Pharmacology, Bromatology and Toxicology, Centro Latinoamericano de Ensenanza e Investigacion en Bacteriologia Alimentaria, Universidad Nacinol Mayor de San Marcos, Lima, Peru.3 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia. 2 Chitkara College of Pharmacy, Chitkara University, Chandigarh, Punjab, India.1 Chitkara College of Pharmacy, Chitkara University, Chandigarh, Punjab, India.The stepping motor and the screw rod are integrated, which makes the laser movement more precise and the coupling more durable. The machine uses an integral screw rod instead of a combined coupling. 410x400mm large area engraving interval can meet your various engraving needs. There are precise scale lines on the X-axis and Y-axis to facilitate quick length measurement. The machine can be compatible with various mature engraving software, such as LaserGRBL, LightBurn, support Win XP / Win 7 / Win 8 / XP / Win 10, and also support MACs system (LightBurn), engraving file format supports NC, BMP, JPG, PNG, DXF etc. Laser power is 5.5-6W, ultra-fine laser focal area is reduced to 0.23mm^2, high-density laser can easily cut 12mm thick wood, black acrylic can engrave stainless steel metal, ceramics. No need to rotate lens to focus, the focal length of the laser is a fixed value, move the lens up and down close to the surface of the object to start carving. The entire structure has been designed for quick assembly, and the assembly can generally be completed within 10-20 minutes. The full-metal structure design makes the machine more solid, it will reduce the vibration of the machine and improves the accuracy of engraving. Solid & Easy Installation Structure Design: Reduce the cost of your goggles and the inconvenience of wearing goggles.Ģ. You and the people around can watch laser engraving without wearing goggles. The laser protective cover perfectly protect your eyes,filter UV light for 95%.